AI Article Synopsis
- The study aimed to investigate whether omega-3 fatty acids, specifically EPA and DHA, can improve mood and impulse control in healthy adults who have low dietary intake of these nutrients.
- A clinical trial involving 272 healthy volunteers tested the effects of 1000 mg of EPA and 400 mg of DHA against a placebo for 18 weeks, measuring mood and impulsivity through questionnaires and brain imaging.
- Results showed no significant changes in mood, impulsive behaviors, or brain function related to affective and impulsive processes after supplementation, indicating that this dosage does not have a notable impact on healthy adults.
Article Abstract
Objective: In clinical trials, omega-3 fatty acid supplementation improves symptoms in psychiatric disorders involving dysregulated mood and impulse control, yet it is unclear whether in healthy adults, omega-3 fatty acid supplementation affects mood, impulse control, and the brain systems supporting these processes. Accordingly, this study tested the hypotheses that eciosapentaenoic (EPA) and docosahexaenoic (DHA) acid supplementation reduces negative affect and impulsive behaviors in healthy adults and that these changes correspond to alterations in corticolimbic and corticostriatal brain systems, which support affective and impulsive processes.
Methods: Healthy volunteers (N = 272) consuming 300 mg/d or less of EPA and DHA were enrolled in a double-blind, randomized, placebo controlled clinical trial. The participants received either capsules providing 1000 mg of EPA and 400 mg of DHA versus identical appearing soybean oil capsules per day for 18 weeks. Negative affect and impulsivity were measured by questionnaire and ecological momentary assessment, as well as functional alterations in corticolimbic and corticostriatal brain systems evoked by standardized functional magnetic resonance imaging tasks.
Results: There were no group by time interactions for any questionnaire or ecological momentary assessment measures of mood and impulsivity. Likewise, no group by time interactions were observed for functional magnetic resonance imaging responses evoked within corticolimbic and corticostriatal systems.
Conclusions: In healthy adults with low intake of omega-3 fatty acids, moderate-dose supplementation for 18 weeks did not alter affect or impulsive behaviors nor alter corticolimbic and corticostriatal brain functionality.
Trial Registration: Trial number NCT00663871.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5453831 | PMC |
| http://dx.doi.org/10.1097/PSY.0000000000000453 | DOI Listing |
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