Twenty-one HLA-A and B antigens were determined in a study of 162 patients with lung cancer. Differences between antigen frequencies in cancer and control populations were determined by chi 2 analysis with Yates correction or Fisher's exact test. Cancer patients had a decreased frequency of the antigen HLA-B40 (pc = 0.003; relative risk = 0.21). In patients with differentiated types of the carcinoma and relatively better prognosis, decreased frequency of the antigen HLA-B40 was found (pc = 0.05; relative risk = 0.27). Our investigation was based on a thorough study of literary data.
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