(Tie Pi Shi Hu in Chinese) has been widely used to treat different diseases in China. Anticancer effect is one of the important effects of . However, the molecular mechanism of its anticancer effect remains unclear. In the present study, gastric carcinogenesis in rats was used to evaluate the effect of on cancer, and its pharmacological mechanism was explored. extracts (4.8 and 2.4 g/kg) were orally administered to the rats of the gastric carcinogenesis model. Compared with the cancer model group, the high dose of extracts significantly inhibited the rate of carcinogenesis. Further analysis revealed that extracts could regulate the DNA damage, oxidative stress, and cytokines related with carcinogenesis and induce cell apoptosis in order to prevent gastric cancer.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5227151 | PMC |
| http://dx.doi.org/10.1155/2016/1213090 | DOI Listing |
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