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Placental PFAS concentrations are associated with perturbations of placental DNA methylation.
Environ Pollut
January 2025
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR; Arkansas Children's Nutrition Center, Little Rock, AR.
The placenta is crucial for fetal development, is affected by PFAS toxicity, and evidence is accumulating that gestational PFAS perturb the epigenetic activity of the placenta. Gestational PFAS exposure can adversely affect offspring, yet individual and cumulative impacts of PFAS on the placental epigenome remain underexplored. Here, we conducted an epigenome-wide association study (EWAS) to examine the relationships between placental PFAS levels and DNA methylation in a cohort of mother-infant dyads in Arkansas (N=151).
View Article and Find Full Text PDFIn Utero Nano-Titanium Dioxide Exposure Results in Sexually Dimorphic Weight Gain and Cardiovascular Function in Offspring.
Cardiovasc Toxicol
January 2025
Department of Physiology, Pharmacology, and Toxicology, West Virginia University, Morgantown, WV, 26505, USA.
Engineered nanomaterials (ENM) are capable of crossing the placental barrier and accumulating in fetal tissue. Specifically, the ENM nano-titanium dioxide (nano-TiO), has been shown to accumulate in placental and fetal tissue, resulting in decreased birthweight in pups. Additionally, nano-TiO is an established cardiac toxicant and regulator of glucose homeostasis, and exposure in utero may lead to serious maladaptive responses in cardiac development and overall metabolism.
View Article and Find Full Text PDFUsing Transcriptomic Signatures to Elucidate Individual and Mixture Effects of Inorganic Arsenic and Manganese in Human Placental Trophoblast HTR-8/SVneo Cells.
Toxicol Sci
January 2025
Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
Prenatal exposure to the toxic metal inorganic arsenic (iAs) is associated with adverse pregnancy and fetal growth outcomes. These adverse outcomes are tied to physiological disruptions in the placenta. While iAs co-occurs in the environment with other metals such as manganese (Mn), there is a gap in the knowledge of the effects of metal-mixtures on the placenta.
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