The final results of radon monitoring in 438 schools located in the province of Lecce (Puglia Region, South Italy) showed an average radon concentration of 215 ± 20 Bq m and that 7% of schools exceeded 500 Bq m, the current Italian action level for radon in workplaces, and consequently required remedial actions. The activity described in the present paper includes the main elements of the remediation project in a subgroup of school buildings. The main radon control systems adopted were sub-slab depressurization (in 57% of schools) and the active ventilation of the crawlspace (in 21% of schools). This experience allows us to put in evidence relevant critical aspects, such as the influence of the karstic nature of the area, the optimization of remediation, the architectural constraints in the case of buildings of architectural or historical interest, which are discussion herein. Moreover, considering the new reference level for radon in workplaces introduced by the new EU Basic Safety Standards, a new analysis of data, achieved in the first survey, highlighted that 20% of schools need to be remediated.
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J Med Internet Res
January 2025
Department of Social Sciences and Health Policy, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, US.
Background: Most cancer survivors have multiple cardiovascular risk factors, increasing their risk of poor cardiovascular and cancer outcomes. The Automated Heart-Health Assessment (AH-HA) tool is a novel electronic health record clinical decision support tool based on the American Heart Association's Life's Simple 7 cardiovascular health (CVH) metrics to promote CVH assessment and discussion in outpatient oncology. Before proceeding to future implementation trials, it is critical to establish the acceptability of the tool among providers and survivors.
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January 2025
Department of Economics, Columbia University, New York, NY 10027.
Measuring and interpreting errors in behavioral tasks is critical for understanding cognition. Conventional wisdom assumes that encoding/decoding errors for continuous variables in behavioral tasks should naturally have Gaussian distributions, so that deviations from normality in the empirical data indicate the presence of more complex sources of noise. This line of reasoning has been central for prior research on working memory.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Department of Chemistry, New York University, New York, NY 10003.
Frameshifting is an essential mechanism employed by many viruses including coronaviruses to produce viral proteins from a compact RNA genome. It is facilitated by specific RNA folds in the frameshift element (FSE), which has emerged as an important therapeutic target. For SARS-CoV-2, a specific 3-stem pseudoknot has been identified to stimulate frameshifting.
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January 2025
Diabetes Center and Department of Laboratory Medicine, University of California, San Francisco, California, USA;
The immune system plays fundamental roles in maintaining physiological homeostasis. With the increasing prevalence of obesity-a state characterized by chronic inflammation and systemic dyshomeostasis-there is growing scientific and clinical interest in understanding how obesity reshapes immune function. In this review, we propose that obesity is not merely an altered metabolic state but also a fundamentally altered immunological state.
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January 2025
Department of Medical Biophysics, Faculty of Medicine and Dentistry, Palacky University, Olomouc, Czech Republic.
The evaluation of large experimental datasets is a fundamental aspect of research in every scientific field. Streamlining this process can improve the reliability of results while making data analysis more efficient and faster to execute. In biomedical research it is often very important to determine the type of cell death after various treatments.
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