AI Article Synopsis

  • * The study examines four specific injury phenotypes in Atlantic haddock embryos caused by crude oil: issues with cardiac development, craniofacial structure, ion regulation, and cholesterol synthesis.
  • * Findings reveal that disruptions in calcium signaling and gene functions are critical to understanding how these developmental issues arise, impacting important processes like heart and jaw formation in marine fish.

Article Abstract

Crude oil spills are a worldwide ocean conservation threat. Fish are particularly vulnerable to the oiling of spawning habitats, and crude oil causes severe abnormalities in embryos and larvae. However, the underlying mechanisms for these developmental defects are not well understood. Here, we explore the transcriptional basis for four discrete crude oil injury phenotypes in the early life stages of the commercially important Atlantic haddock (). These include defects in (1) cardiac form and function, (2) craniofacial development, (3) ionoregulation and fluid balance, and (4) cholesterol synthesis and homeostasis. Our findings suggest a key role for intracellular calcium cycling and excitation-transcription coupling in the dysregulation of heart and jaw morphogenesis. Moreover, the disruption of ionoregulatory pathways sheds new light on buoyancy control in marine fish embryos. Overall, our chemical-genetic approach identifies initiating events for distinct adverse outcome pathways and novel roles for individual genes in fundamental developmental processes.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302885PMC
http://dx.doi.org/10.7554/eLife.20707DOI Listing

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