Green microalgae contain many active pigments such as carotenoids having antioxidant and protective activity on human cells. Here we investigate the biological activity of an ethanol/water extract of the marine green microalga Tetraselmis suecica containing high levels of carotenoids such as the xanthophylls lutein, violaxanthin, neoxanthin, antheraxanthin and loroxanthin esters. This extract has a strong antioxidant and repairing activity in the human lung cancer cell line (A549) as shown by the increased expression of dehydrocholesterol reductase-24 (DHCR24) and prostaglandin reductase 1 (PTGR1) genes and proteins. The extract also reduces prostaglandin E (PGE) levels in cells damaged by HO and has tissue repairing effects on reconstructed human epidermal tissue cells (EpiDerm) indicating a potential cosmeceutical activity of this microalgal species.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5259714 | PMC |
http://dx.doi.org/10.1038/srep41215 | DOI Listing |
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