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Prognostic significance of CD3+ and CD8+ T-cells immunoscore in renal cell carcinoma: A comparison between two simple models for assessment.
Ann Diagn Pathol
December 2024
Department of Pathology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt; Department of Pathology, College of Medicine, Jouf University, 2004 Sakaka 42421, Saudi Arabia.
The immunoscore (ISc) has been extensively investigated as a prognostic indicator for numerous solid tumors. In renal cell carcinoma (RCC), its prognostic significance has been evaluated in a small number of studies. This study was designed to ascertain the prognostic value of ISc based on CD3+ and CD8+ T cells in patients with RCC.
View Article and Find Full Text PDFA biopsy-based Immunoscore in patients with treatment-naïve resectable gastric cancer.
Ther Adv Med Oncol
October 2024
Department of Pathology, Amsterdam UMC location VUmc, Amsterdam, Vrije Universiteit Amsterdam, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.
Background: The prognostic significance of T-cell densities in gastric cancer (GC) was previously demonstrated in surgical resection specimens. For prognosis or response prediction, it is preferable to identify biomarkers in pre-treatment biopsies; yet, its representativeness of the tumor immune microenvironment is unclear.
Objectives: This study aimed to evaluate the concordance and prognostic value of T-cell densities in paired biopsies and resections.
Prognostic and Predictive Value of a Modified Diagnostic Biopsy-Adapted Immunoscore in Patients with Rectal Cancer After Neoadjuvant Treatment: A Translational Study From the STELLAR Trial.
Int J Radiat Oncol Biol Phys
October 2024
Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. Electronic address:
Purpose: The purpose of this study was to assess the prognostic significance of the modified diagnostic biopsy-adapted immunoscore (mIS) in determining the outcomes for patients with locally advanced rectal cancer (LARC) in a neoadjuvant setting.
Methods And Materials: We included 181 patients with LARC from a single subcenter of a prospective study comparing total neoadjuvant therapy (TNT) based on short-course radiation therapy with long-term chemoradiation therapy (CRT). Tumor biopsies at baseline were stained for CD8+ and CD3+ T-cell densities.
Immunoproteomics Reveal Different Characteristics for the Prognostic Markers of Intratumoral-Infiltrating CD3+ T Lymphocytes and Immunoscore in Colorectal Cancer.
Lab Invest
December 2024
Department of Pathology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:
Tumor-infiltrating lymphocytes (TILs) and immunoscoring based on densities of CD3+ and CD8+ TILs are both favorable prognostic markers in colorectal cancer (CRC). However, determination of the molecular features of TILs, particularly their immunoproteomic signatures would require the development of large scale in situ spatiotemporal technologies. Recently, a multiplex in situ digital spatial proteomic profiling (DSP) tool GeoMx DSP has been applied to identify biomarkers predictive of therapeutic responses and to understand disease mechanisms and progression.
View Article and Find Full Text PDFExploring the impact of tertiary lymphoid structures maturity in NSCLC: insights from TLS scoring.
Front Immunol
October 2024
Translational Medicine, Oncology R&D, AstraZeneca, Cambridge, United Kingdom.
Article Synopsis
- Tertiary Lymphoid Structures (TLS) are linked to better cancer patient survival and responses to immunotherapies, but their effectiveness can vary based on size, composition, and maturation.
- A study on Non-Small Cell Lung Carcinoma (NSCLC) used a multiplex immunofluorescent panel to analyze tumor samples from 406 patients, focusing on specific immune cell types within TLS.
- The analysis led to a TLS scoring system that identified key features predictive of patient outcomes, showing correlations with other cancer biomarkers but not with PD-L1 status.
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