Utility of real-time prospective motion correction (PROMO) for segmentation of cerebral cortex on 3D T1-weighted imaging: Voxel-based morphometry analysis for uncooperative patients.

Objective: To assess the utility of the motion correction method with prospective motion correction (PROMO) in a voxel-based morphometry (VBM) analysis for 'uncooperative' patient populations.

Methods: High-resolution 3D T1-weighted imaging both with and without PROMO were performed in 33 uncooperative patients with Parkinson's disease (n = 11) or dementia (n = 22). We compared the grey matter (GM) volumes and cortical thickness between the scans with and without PROMO.

Results: For the mean total GM volume with the VBM analysis, the scan without PROMO showed a significantly smaller volume than that with PROMO (p < 0.05), which was caused by segmentation problems due to motion during acquisition. The whole-brain VBM analysis showed significant GM volume reductions in some regions in the scans without PROMO (familywise error corrected p < 0.05). In the cortical thickness analysis, the scans without PROMO also showed decreased cortical thickness compared to the scan with PROMO (p < 0.05).

Conclusion: Our results with the uncooperative patients indicate that the use of PROMO can reduce misclassification during segmentation of the VBM analyses, although it may not prevent GM volume reduction.

Key Points: • Motion artifacts pose significant problems for VBM analyses. • PROMO correction can reduce the motion artifacts in high-resolution 3D T1WI. • The use of PROMO may improve the precision of VBM analyses.