AI Article Synopsis
- The study investigates complications in spinal surgery for osteoporotic patients, comparing teriparatide and bisphosphonates.
- 58 Japanese female patients were divided into two groups, with one receiving teriparatide and the other low-dose bisphosphonates during surgery.
- Results indicated that patients on bisphosphonates had more complications like fractures and poor pain management, suggesting teriparatide is more beneficial for these surgeries.
Article Abstract
Purpose: Complications of adult spinal deformity surgery are problematic in osteoporotic individuals. We compared outcomes between Japanese patients treated perioperatively with teriparatide vs. low-dose bisphosphonates.
Methods: Fifty-eight osteoporotic adult Japanese female patients were enrolled and assigned to perioperative teriparatide (33 patients) and bisphosphonate (25 patients) groups in non-blinded fashion. Pre- and post-operative X-ray and computed tomography imaging were used to assess outcome, and rates were compared between the groups and according to age. Pain scores and Oswestry Disability Indices (ODI) were calculated before and 2 years after surgery.
Results: Adjacent vertebral fractures and implant failure, fusion failure, and poor pain and ODI outcomes were significantly more common in the bisphosphonates group than the teriparatide group.
Conclusions: Perioperative administration of teriparatide is more effective than that of low-dose bisphosphonates in preventing complications and maintaining fusion rates in osteoporotic Japanese females with spinal deformities undergoing surgery.
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| http://dx.doi.org/10.1007/s00586-017-4959-0 | DOI Listing |
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