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Anti-IL-5 biologics and rheumatoid arthritis: a single-centre 500 patient year exposure analysis.
RMD Open
December 2023
Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Chapel Allerton Hospital, Leeds, UK.
Objective: The increasing use of biological therapies has led to the paradoxical finding that monoclonal antibody therapy for one inflammatory disease can sometimes induce another inflammatory disease. Recently, the use of anti-IL-5 (IL, interleukin) antibody therapies for severe asthma has been associated with the onset of rheumatoid arthritis (RA) and other inflammatory rheumatological disease. We undertook this audit to identify the prevalence of this finding across a large clinical cohort of patients receiving anti-IL-5 therapy.
View Article and Find Full Text PDFRheumatoid arthritis prevention in arthralgia: fantasy or reality?
Nat Rev Rheumatol
December 2023
Department of Rheumatology, Leiden University Medical Centre, Leiden, the Netherlands.
The concept of a 'window of opportunity' in treating a disease assumes the existence of a time frame during which the trajectory of the disease can be effectively and permanently modified. In rheumatoid arthritis (RA), optimal timing of this period is presumed to be during the phase before arthritis is clinically apparent and disease is diagnosed. Several proof-of-concept trials of treatment during the 'arthralgia' phase of RA have been completed in the past 4 years, with the underlying notion that temporary treatment at this stage could prevent the development of RA or induce a sustained reduction in the burden of disease.
View Article and Find Full Text PDFMediating Effect of Pain Sensitization on the Paradoxical Relation of Taking Opioids to Pain Severity in Knee Osteoarthritis: The Multicenter Osteoarthritis Study.
Arthritis Care Res (Hoboken)
March 2024
Boston University Chobanian & Avedisian School of Medicine, Boston, Massachusetts.
Objective: One of the less understood adverse effects while taking opioids is the paradoxical increase in pain, known as opioid-induced hyperalgesia (OIH). We sought to determine whether pain sensitization mediates the relation of taking an opioid to pain severity in people with knee osteoarthritis (OA).
Methods: We included participants in a National Institutes of Health-funded cohort study of people with or at risk of knee OA.
Erythema nodosum after golimumab treatment in ankylosing spondylitis patients: a case report and literature review.
Ann Med Surg (Lond)
September 2023
Faculty of Medicine, Damascus University.
Introduction: Erythema nodosum (EN) is a self-limited septal panniculitis that presents with fever, arthralgia, and arthritis. Tumor necrosis factor alpha (TNF-α) inhibitor such as golimumab has been found to treat EN in inflammatory bowel diseases (IBD). We herein report the paradoxical occurrence of EN following golimumab for ankylosing spondylitis.
View Article and Find Full Text PDFA Case of Paradoxical Arthralgia Following Anti-TNF Monoclonal Antibody Administration in a Patient With New-Onset Pediatric Crohn's Disease.
JPGN Rep
May 2023
Ospedale Infantile Regina Margherita, Città della salute e della scienza di Torino, Turin, Italy.
Anti-TNF antibodies have become a first-line therapy in moderate-to-severe inflammatory bowel diseases. However, there may be some rare paradoxical events and those affecting joints causing severe symptoms need a scrupulous differential diagnosis. When these events occur, it may be necessary to discontinue treatment and shift to another drug class.
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