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SPRINT Treatment Among Adults With Chronic Kidney Disease From 2 Large Health Care Systems.
JAMA Netw Open
January 2025
Division of Nephrology, Department of Medicine, Stanford University School of Medicine, Palo Alto, California.
Importance: It is unclear whether the effects of intensive vs standard blood pressure (BP) targets seen in clinical trials generalize to patients with chronic kidney disease (CKD) encountered in everyday practice due to differences in the distribution of cardiovascular risk factors and coexisting conditions.
Objective: To evaluate whether the beneficial and adverse effects of intensive vs standard BP control observed in the Systolic Blood Pressure Intervention Trial (SPRINT) are transportable to a target population of adults with CKD in clinical practice.
Design, Setting, And Participants: This comparative effectiveness study identified 2 populations with CKD who met the eligibility criteria for SPRINT between January 1 and December 31, 2019, in the Veterans Health Administration (VHA) and Kaiser Permanente of Southern California (KPSC).
Association Between Kidney Disease Index and Decline in Cognitive Function with Mediation by Arterial Stiffness in Asians with Type 2 Diabetes.
J Alzheimers Dis Rep
September 2024
Diabetes Centre, Admiralty Medical Centre, Singapore, Singapore.
Article Synopsis
- The study explores the link between kidney function, as measured by the Kidney Disease Index (KDI), and cognitive function in individuals with type 2 diabetes, focusing on how arterial stiffness may play a role in this relationship.! -
- It finds that lower KDI scores correlate with poorer cognitive performance on assessments, especially in areas like immediate memory and attention, over a follow-up period of up to 8.6 years.! -
- The findings suggest that impaired kidney function could hinder cognitive abilities, potentially mediated by the impacts of arterial stiffness on the brain's blood flow.
Biomarker Profiling with Targeted Metabolomic Analysis of Plasma and Urine Samples in Patients with Type 2 Diabetes Mellitus and Early Diabetic Kidney Disease.
J Clin Med
August 2024
Department of Internal Medicine II, Division of Nephrology, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania.
: Over the years, it was noticed that patients with diabetes have reached an alarming number worldwide. Diabetes presents many complications, including diabetic kidney disease (DKD), which can be considered the leading cause of end-stage renal disease. Current biomarkers such as serum creatinine and albuminuria have limitations for early detection of DKD.
View Article and Find Full Text PDFEndocrine-Disrupting Chemicals Exposure and Neurocognitive Function in the General Population: A Community-Based Study.
Toxics
July 2024
College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Background: Endocrine-disrupting chemicals (EDCs) are pervasive in everyday environments. The impacts of these chemicals, along with EDC-related lifestyle and dietary habits on neurocognitive function, are not well understood.
Methods: The Chang Gung Community Medicine Research Center conducted a cross-sectional study involving 887 participants.
Biomarkers of chronic kidney disease in older individuals: navigating complexity in diagnosis.
Front Med (Lausanne)
July 2024
Unit of Geriatric Medicine, Italian National Research Center on Aging (IRCCS INRCA), Cosenza, Italy.
Chronic kidney disease (CKD) in older individuals is a matter of growing concern in the field of public health across the globe. Indeed, prevalence of kidney function impairment increases with advancing age and is often exacerbated by age-induced modifications of kidney function, presence of chronic diseases such as diabetes, hypertension, and cardiovascular disorders, and increased burden related to frailty, cognitive impairment and sarcopenia. Accurate assessment of CKD in older individuals is crucial for timely intervention and management and relies heavily on biomarkers for disease diagnosis and monitoring.
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