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Comparison of Prevalence and Types of Mutations in Lung Cancers Among Black and White Populations. | LitMetric

AI Article Synopsis

  • Lung cancer is the top cause of cancer-related deaths in the U.S., with black patients having a higher death rate compared to white patients.
  • The study aimed to examine the differences in genetic mutations between lung cancers in black and white patients to improve treatment strategies.
  • Analysis of tumor samples showed no significant differences in mutation frequencies or specific genetic changes between the two groups, suggesting that lung cancers in black and white patients may be more similar than previously thought.

Article Abstract

Importance: Lung cancer is the leading cause of cancer death in the United States in all ethnic and racial groups. The overall death rate from lung cancer is higher in black patients than in white patients.

Objective: To compare the prevalence and types of somatic alterations between lung cancers from black patients and white patients. Differences in mutational frequencies could illuminate differences in prognosis and lead to the reduction of outcome disparities by more precisely targeting patients' treatment.

Design, Setting, And Participants: Tumor specimens were collected from Baptist Cancer Center (Memphis, Tennessee) over the course of 9 years (January 2004-December 2012). Genomic analysis by massively parallel sequencing of 504 cancer genes was performed at Dana-Farber Cancer Institute (Boston, Massachusetts). Overall, 509 lung cancer tumors specimens (319 adenocarcinomas; 142 squamous cell carcinomas) were profiled from 245 black patients and 264 white patients.

Main Outcomes And Measures: The frequencies of genomic alterations were compared between tumors from black and white populations.

Results: Overall, 509 lung cancers were collected and analyzed (273 women [129 black patients; 144 white patients] and 236 men [116 black patients; 120 white patients]). Using 313 adenocarcinomas and 138 squamous cell carcinomas with genetically supported ancestry, overall mutational frequencies and copy number changes were not significantly different between black and white populations in either tumor type after correcting for multiple hypothesis testing. Furthermore, specific activating alterations in members of the receptor tyrosine kinase/Ras/Raf pathway including EGFR and KRAS were not significantly different between populations in lung adenocarcinoma.

Conclusions And Relevance: These results demonstrate that lung cancers from black patients are similar to cancers from white patients with respect to clinically actionable genomic alterations and suggest that clinical trials of targeted therapies could significantly benefit patients in both groups.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5464986PMC
http://dx.doi.org/10.1001/jamaoncol.2016.6108DOI Listing

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