We propose a probabilistic graphical framework for multi-instance learning (MIL) based on Markov networks. This framework can deal with different levels of labeling ambiguity (i.e., the portion of positive instances in a bag) in weakly supervised data by parameterizing cardinality potential functions. Consequently, it can be used to encode different cardinality-based multi-instance assumptions, ranging from the standard MIL assumption to more general assumptions. In addition, this framework can be efficiently used for both binary and multiclass classification. To this end, an efficient inference algorithm and a discriminative latent max-margin learning algorithm are introduced to train and test the proposed multi-instance Markov network models. We evaluate the performance of the proposed framework on binary and multi-class MIL benchmark datasets as well as two challenging computer vision tasks: cyclist helmet recognition and human group activity recognition. Experimental results verify that encoding the degree of ambiguity in data can improve classification performance.
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Sci Rep
January 2025
Department of Computer Science and Engineering, Amrita School of Computing, Amrita Vishwa Vidyapeetham, Bengaluru, India.
The growing integration of renewable energy sources within microgrids necessitates innovative approaches to optimize energy management. While microgrids offer advantages in energy distribution, reliability, efficiency, and sustainability, the variable nature of renewable energy generation and fluctuating demand pose significant challenges for optimizing energy flow. This research presents a novel application of Reinforcement Learning (RL) algorithms-specifically Q-Learning, SARSA, and Deep Q-Network (DQN)-for optimal energy management in microgrids.
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January 2025
Department of Chemistry, Theoretical Chemistry Institute, University of Wisconsin-Madison, Madison, WI, 53706, USA.
Identifying transitional states is crucial for understanding protein conformational changes that underlie numerous biological processes. Markov state models (MSMs), built from Molecular Dynamics (MD) simulations, capture these dynamics through transitions among metastable conformational states, and have demonstrated success in studying protein conformational changes. However, MSMs face challenges in identifying transition states, as they partition MD conformations into discrete metastable states (or free energy minima), lacking description of transition states located at the free energy barriers.
View Article and Find Full Text PDFChaos
January 2025
Department of Management Science and Technology, Tohoku University, Sendai 980-8579, Japan.
Complex network approaches have been emerging as an analysis tool for dynamical systems. Different reconstruction methods from time series have been shown to reveal complicated behaviors that can be quantified from the network's topology. Directed recurrence networks have recently been suggested as one such method, complementing the already successful recurrence networks and expanding the applications of recurrence analysis.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Cleveland Clinic, Cleveland, OH, USA.
Background: Apolipoprotein E (ApoE) is the primary cholesterol and lipid transporting apolipoprotein in the central nervous system (CNS) and is the greatest genetic risk factor for Alzheimer's Disease (AD). There are three main isoforms differing by single amino acid changes: ε3 is "neutral", ε4 is "risk" (Cys112Arg), and ε2 is "resilience" (Arg158Cys). Rare forms (Christchurch, Jacksonville) have also been proposed as resilience alleles, while an ε4-like allele (with Arg61Thr) is present in non-human primates without AD risk.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Trinity Biomedical Sciences Institute, Trinity College Dublin, University of Dublin, Dublin, Dublin 2, Ireland.
Background: Amyotrophic lateral sclerosis (ALS) shares pathological and genetic underpinnings with frontotemporal dementia (FTD). ALS manifests with diverse symptoms, including progressive neuro-motor degeneration, muscle weakness, but also cognitive-behavioural changes in up to half of the cases. Resting-state EEG measures, particularly spectral power and functional connectivity, have been instrumental for discerning abnormal motor and cognitive network function in ALS [1]-[3].
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