AI Article Synopsis
- Researchers are exploring nanocarriers like p-sulfocalix[6]arene to reduce the side effects of the toxic chemotherapy drug doxorubicin (DOX) while effectively delivering it to cancer cells.
- The study examined how DOX binds to both the calixarene and DNA, revealing that DOX has a much stronger affinity for DNA compared to the calixarene.
- Cytotoxicity tests show that encapsulating DOX in calixarenes lowers its toxicity in various cancer and normal cell lines, indicating a potential strategy for safer drug delivery.
Article Abstract
Given the high toxicity of the anthracycline antibiotic doxorubicin (DOX), it is relevant to search for nanocarriers that decrease the side effects of the drug and are able to transport it towards a therapeutic target Here, the encapsulation of DOX by p-sulfocalix[6]arene (calix) has been studied. The interaction of DOX with the macrocycle, as well as with DNA, has been investigated and the equilibrium constant for each binding process estimated. The results showed that the binding constant of DOX to DNA, K , is three orders of magnitude higher than that to calix, K . The ability of calixarenes to encapsulate DOX molecules, as well as the capability of the DOX molecules included into the inner cavity of the macrocycle to bind with DNA have been examined. Cytotoxicity measurements were done in different cancer and normal cell lines to probe the decrease in the toxicity of the encapsulated DOX. The low toxicity of calixarenes has also been demonstrated for different cell lines.
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| http://dx.doi.org/10.1002/asia.201601713 | DOI Listing |
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