AI Article Synopsis
- Rhubarb, specifically Rheum tanguticum, contains active compounds like anthraquinones and tannins, and researchers developed a new analytical method (UPLC/Q-TOF-MS/MS) to identify these constituents.
- The method was applied for the first time to study R. tanguticum, successfully separating compounds and evaluating their fragmentation pathways in negative ion mode.
- In total, 30 constituents were identified, including seven not previously reported for R. tanguticum and two new for the Rheum genus, showcasing the method's efficiency in analyzing complex plant extracts.
Article Abstract
Rhubarb contains biologically active compounds such as anthraquinones, anthrones, stilbenes and tannins. A rapid and efficient UPLC/Q-TOF-MS/MS method was developed and applied towards identifying the constituents of Rheum tanguticum Maxim. ex Balf. for the first time. Chemical constituents were separated and investigated by UPLC/Q-TOF-MS/MS in the negative ion mode. The ESI-MS fragmentation pathways of four types of compounds were interpreted, providing a very useful guidance for the characterisation of different types of compounds. Based on the exact mass information, fragmentation characteristic and LC retention time of 7 reference standards, 30 constituents were tentatively identified from the methanol extract of R. tanguticum. Among them, seven compounds were described for the first time from R. tanguticum and two from the genus Rheum were described for the first time. The analytical tool used here is valuable for the rapid separation and identification of multiple and minor constituents in methanol extracts of R. tanguticum.
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| http://dx.doi.org/10.1080/14786419.2017.1280491 | DOI Listing |
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