AI Article Synopsis
- The study introduces a method to release drugs using photo-unclick chemistry, triggered by singlet oxygen (SO), which can be activated by visible light and near-infrared light.
- The research combines a photosensitizer and an SO-cleavable drug linker into one molecule or within drug delivery systems to enhance localized drug activation.
- The results demonstrate successful activation of a specific prodrug using a mitochondria-targeting photosensitizer, highlighting a novel approach to controlled drug release.
Article Abstract
Photo-unclick chemistry mediates visible and near IR-controlled drug release via a singlet oxygen (SO)-cleavable linker. Due to the limited diffusion distance of SO in biological systems, a photosensitizer and the SO-cleavable linker have been conjugated in one molecule or mixed in nano-drug delivery systems. In this communication, we demonstrate a new strategy to activate prodrugs with photo-unclick chemistry in an intermolecular fashion using an SO-cleavable CA4 prodrug and a mitochondria-specific photosensitizer, protoporphyrin IX, formed from prodrug hexyl-5-aminolevulinate.
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| http://dx.doi.org/10.1039/c6cc09994g | DOI Listing |
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