[Effect of isoptin on catecholamine levels in arterial and coronary venous blood during an attack of myocardial ischemia].

Blood catecholamines (dopamine, adrenaline and noradrenaline) were measured in the coronary sinus and artery of 35 patients divided into 2 groups: coronary patients with stable angina of effort, functional class II-III (group 1) and patients with NCD (group 2), before and during a cardioselective load test (atrial stimulation). Developing myocardial ischemia was associated with a significant rise of noradrenaline in arterial and coronary venous blood. The use of isoptin changed noradrenaline balance, resulting in increased noradrenaline level in the coronary sinus, while coronary flow increased, as did the anginal threshold. Noradrenaline rise may well be an additional antianginal factor mediating the action of isoptin.