Introduction: Bilateral interictal epileptiform discharges (IED) and ictal patterns are common in temporal lobe epilepsy (TLE) and have been associated with decreased chances of seizure freedom after epilepsy surgery. It is unclear whether secondary epileptogenesis, although demonstrated in experimental models, exists in humans and may account for progression of epilepsy.
Material And Methods: We reviewed consecutive video-EEG recordings from 1992 to 2014 repeated at least two years apart (mean interval 6.14years) in 100 people diagnosed with TLE.
Results: Ictal EEG patterns and IED remained restricted to one hemisphere in 36 people (group 1), 46 exhibited bilateral abnormalities from the first recording (group 2), 18 progressed from unilateral to bilateral EEG pathology over time (group 3). No significant differences between the three groups were seen with respect to age at epilepsy onset, duration, or underlying pathology. Extra-temporal IED during the first EEG recording were associated with an increased risk of developing bilateral epileptiform changes over time (hazard ratio 3.67; 95% CI 1.4, 9.4).
Conclusion: Our findings provide some support of progression in TLE and raise the possibility of secondary epileptogenesis in humans. The development of an independent contra-lateral epileptogenic focus is known to be associated with a less favorable surgical outcome. We defined reliable EEG markers for an increased risk of progression to more widespread or independent bitemporal epileptogenicity at an early stage, thus allowing for individualized pre-surgical counselling.
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http://dx.doi.org/10.1016/j.yebeh.2016.12.027 | DOI Listing |
J Clin Med
January 2025
Department of Epileptology, University Hospital Bonn (UKB), 53127 Bonn, Germany.
In light of the growing interest in the bidirectional relationship between epilepsy and dementia, this review aims to provide an overview of the role of hyperphosphorylated tau (pTau) in cognition in human epilepsy. A literature search identified five relevant studies. All of them examined pTau burden in surgical biopsy specimens from patients with temporal lobe epilepsy.
View Article and Find Full Text PDFBrain Lang
January 2025
Department of Veterans Affairs Rehabilitation Research and Development Brain Rehabilitation Research Center at the Malcom Randall VA Medical Center, Gainesville, FL 32608, USA; University of Florida Department of Neurology, Gainesville, FL 32610, USA; Neurology Service, North Florida/South GeorgiaUSA Veterans Health System and Department of Neurology, University of Florida, Gainesville, FL 32608, USA. Electronic address:
Introduction: Although many white matter tracts underlying language functions have been identified, even in aggregate they do not provide a sufficiently detailed and expansive picture to enable us to fully understand the computational processes that might underly language production and comprehension. We employed diffusion tensor tractography (DTT) with a tensor distribution model to more extensively explore the white matter tracts supporting core language functions. Our study was guided by hypotheses stemming largely from the aphasia literature.
View Article and Find Full Text PDFRINCH (Rhythmic Ictal Non-Clonic Hand movements), a lateralizing sign in frontotemporal epilepsy, has been well described in the adult epilepsy population but not in the pediatric setting. We looked for evidence of RINCH as an ictal sign in pediatric epilepsy monitoring unit reports in a large academic pediatric hospital. We found nine patients with RINCH ictal phenomenon over a five-year period.
View Article and Find Full Text PDFClin Radiol
December 2024
Department of Neurology, The Second Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China. Electronic address:
Aim: To provide a theoretical basis for the study of the pathogenesis of residual dizziness (RD) from the perspective of imaging.
Materials And Methods: The general clinical data of the RD group and healthy control (HC) group were statistically analysed by two independent sample t tests, rank sum tests or chi-square tests. The imaging data of the two groups of people were preprocessed and statistically analysed by using the data processing and analysis for brain imaging (DPABI) software package.
J Neurosurg
January 2025
Departments of1Biomedical Engineering.
Objective: Epilepsy is a common neurological disease affecting nearly 1% of the global population, and temporal lobe epilepsy (TLE) is the most common type. Patients experience recurrent seizures and chronic cognitive deficits that can impact their quality of life, ability to work, and independence. These cognitive deficits often extend beyond the temporal lobe and are not well understood.
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