This study was proposed to study the myocardial protective effect of allopurinol clinically. This study involved 65 patients undergone coronary artery bypass operations or cardiac valve replacements or plasties. Patients were divided into two groups: group I, 30 patients received 2,400 mg of allopurinol preoperatively; group II, 35 patients undergoing no treatment of allopurinol. Postoperative values of GOT, CK-MB and LDH1 + LDH2 in group I were significantly lower than that of group II. These results suggest that allopurinol has advantageous effect on myocardial protection.
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