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Pulmonary granuloma formation during latent infection in C3HeB/FeJ mice involves progression through three immunological phases.
mBio
January 2025
Department of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota, USA.
is a fungal pathogen that can cause lethal disease in immunocompromised patients. Immunocompetent host immune responses, such as formation of pulmonary granulomas, control the infection and prevent disseminated disease. Little is known about the immunological conditions establishing the latent infection granuloma in the lungs.
View Article and Find Full Text PDFoil induces oxidative stress, stiffening of membranes, and cell wall in spp.
Can J Microbiol
January 2025
Postgraduation Program in Cellular and Molecular Biology, Federal University of Rio Grande do Sul - Porto Alegre, RS 91501-970, Brazil.
Article Synopsis
- Cryptococcosis, caused by specific fungal species, leads to 181,000 deaths annually due to late diagnosis and limited treatment, highlighting the need for new antifungal agents like essential oils.
- The study investigated how lavender essential oil (LEO) affects two strains of fungi, utilizing molecular evaluation through morphological and proteomics approaches.
- Results showed that LEO induces a stressful environment; one strain exhibited changes in energy metabolism, while the other showed alterations in cellular architecture, indicating differences in their responses to the treatment.
Unusual late presentation of cryptococcal meningitis with simultaneous CMV antigenemia in a kidney transplant recipient.
CEN Case Rep
October 2024
Department of Medicine, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong SAR, China.
Cryptococcosis is the third most common invasive fungal infection in solid-organ transplant (SOT) recipients after candidiasis and aspergillosis. These patients are at risk of disseminated cryptococcosis because of immuosuppressive therapy. The median time to disease onset after kidney transplantation is approximately 35 months and it rarely occurs more than 10 years after transplantation.
View Article and Find Full Text PDFLate Relapse of Previous Pulmonary Cryptococcosis With Symptoms Resembling Cerebral Infarction: A Case Report.
Case Rep Infect Dis
October 2024
Department of Neurosurgery, Otto-Von-Guericke-University Magdeburg, Magdeburg, Germany.
Cryptococcosis, an infection caused by , predominantly targets the central nervous system (CNS) in patients with AIDS but is not limited to this group. The disease can also occur in individuals with various immunosuppressive conditions, frequently involving the brain or lungs. Cryptococcal meningitis (CM) is the most common form of fungal meningoencephalitis, leading to intracerebral infections, cerebral infarction, or hydrocephalus.
View Article and Find Full Text PDFThe significance of low titer serum cryptococcal antigen testing from 2017 to 2023 performed in a tertiary care center.
Med Mycol
September 2024
Department of Pathology and Laboratory Medicine, University of Kentucky, Lexington, KY 40536, USA.
Several false positive low serum cryptococcal antigen (SCrAg) reports by lateral flow assay (LFA) were identified in late 2016 at our tertiary care hospital. After the recall and correction of the problem in the reagent, we studied the significance of SCrAg LFA ≤ 1:10 from January 2017 to October 2023. Of 20 patients with 31 samples of SCrAg LFA ≤ 1:10, 14 patients (70%) were classified as true positives, four (20%) were indeterminate, and only two (10%) patients were false positives.
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