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A US-Based Multi-Site Pilot to Screen Hepatitis B Surface Antigen-Positive Patients for Hepatitis D.
J Viral Hepat
January 2025
Infectious Disease/Family Treatment Center, Newark Beth Israel Medical Center, Newark, New Jersey, USA.
Hepatitis D (HDV) is a severe infection with well-recognised clinical ramifications that remains relatively neglected and underdiagnosed; consequently, the epidemiology of HDV is poorly characterised, both in the United States and globally. In 2022, a pilot project involving eight healthcare institutions was undertaken to ascertain the prevalence of HDV in healthcare institutions with an HBV seropositivity of at least 1%, describe the characteristics of patients testing positive for HDV, and evaluate diagnostic and laboratory processes of HDV screening. From August 2022 to April 2024, a total of 106,693 patients were tested for HBsAg, of whom 65,341 (61.
View Article and Find Full Text PDFSingle-chain nanobody inhibition of Notch and avidity enhancement utilizing the β-pore forming toxin Aerolysin.
bioRxiv
October 2024
University of Minnesota, Twin Cities. Minneapolis, MN 55409.
Article Synopsis
- Notch is important for development and diseases, leading researchers to create inhibitors using small molecules and antibodies.* -
- A novel nanobody was developed to inhibit Notch signaling, showing effectiveness in laboratory assays despite a low affinity for the Notch target.* -
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Retraction Note: Mask-related costs in measuring preview benefit: Evidence from a distributional analysis based on target word reading times.
Atten Percept Psychophys
October 2024
Department of Psychology & Neuroscience, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Hypoxanthine in the microenvironment can enable thiopurine resistance in acute lymphoblastic leukemia.
Front Oncol
July 2024
Division of Pediatric Hematology and Oncology, Department of Pediatrics, University of Minnesota, Minneapolis, MN, United States.
Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy, with relapse being a major obstacle to successful treatment. Our understanding of the mechanisms driving chemotherapy resistance and ultimately relapse in leukemia remains incomplete. Herein, we investigate the impact of the tumor microenvironment on leukemia cell drug responses using human plasma-like media (HPLM), designed to mimic physiological conditions more accurately .
View Article and Find Full Text PDFNarrative Ability in Autism and First-Degree Relatives.
J Autism Dev Disord
July 2024
Northwestern University, 2240 Campus Drive, Frances Searle Building, #2-366, Evanston, IL, 6020, USA.
Narrative is an important communication skill for sharing personal experiences and connecting with others. Narrative skills are often impacted in autism spectrum disorder (ASD) and have important consequences for social interactions and relationships. Subtle differences in narrative have also been reported among first-degree relatives of autistic individuals, suggesting that narrative may also be an etiologically important language-related skill that is influenced by genes associated with ASD.
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