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Standardized therapies after ECMO program (STEP); a novel approach to pediatric post-ECMO care.

J Extra Corpor Technol

September 2024

Department of Pediatrics, Division of Critical Care, University of Tennessee Health Science Center, Memphis, TN 38103, USA - Le Bonheur Children's Hospital, Memphis, TN 38103, USA.

Article Synopsis
  • - The study evaluated the STEP program, aimed at improving post-discharge care for pediatric ECMO survivors in a hospital setting, focusing on guideline compliance.
  • - After implementing STEP, there was a significant increase in the compliance rates for neurodevelopmental testing and follow-up evaluations in various therapeutic areas (e.g., neurology, audiology) among patients.
  • - The results showed that STEP effectively enhanced adherence to follow-up guidelines, resulting in more timely and thorough neurodevelopmental assessments for ECMO survivors.
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Background: The COVID-19 pandemic has disrupted routine hospital services globally. This study estimated the total number of adult elective operations that would be cancelled worldwide during the 12 weeks of peak disruption due to COVID-19.

Methods: A global expert response study was conducted to elicit projections for the proportion of elective surgery that would be cancelled or postponed during the 12 weeks of peak disruption.

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Objective: Genome sequencing (GS) is promising for unsolved leukodystrophies, but its efficacy has not been prospectively studied.

Methods: A prospective time-delayed crossover design trial of GS to assess the efficacy of GS as a first-line diagnostic tool for genetic white matter disorders took place between December 1, 2015 and September 27, 2017. Patients were randomized to receive GS immediately with concurrent standard of care (SoC) testing, or to receive SoC testing for 4 months followed by GS.

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Background: The Clavien-Dindo classification is perhaps the most widely used approach for reporting postoperative complications in clinical trials. This system classifies complication severity by the treatment provided. However, it is unclear whether the Clavien-Dindo system can be used internationally in studies across differing healthcare systems in high- (HICs) and low- and middle-income countries (LMICs).

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