Serum trace elements are interrelated with hormonal imbalance in men with acute ischemic stroke.

Unlabelled: The objective of the present study was to assess hormonal and trace element status in men suffering from acute ischemic stroke.

Methods: 21 acute ischemic stroke patients and 21 age- and body mass index-matched healthy volunteers were enrolled in the study. Serum trace elements were assessed using inductively coupled plasma mass spectrometry. Serum hormones and brain damage markers were estimated using enzyme-linked immunosorbent assay.

Results: Ischemic stroke patients are characterized by significantly higher levels of total and free triiodothyronine (T), anti-thyroid peroxidase antibodies (Anti-TPO-Ab), prolactin, and cortisol, whereas the level of thyroid stimulating hormone (TSH) was decreased. Serum B, Cu, Li, Mn, Ni, Pb, Se, V, and Zn in stroke significantly exceeded the control values, whereas the level of Co and Fe was decreased. Correlation analysis revealed a significant association between serum B and T, Anti-TPO-Ab, and iodine concentration; serum Li and Sr levels - with circulating TSH, free T3, and Anti-TPO-Ab; and V concentration - with total T and I levels. The following positive relationships were also revealed: Co - TSH, Mn - free T, Zn - free T. Multiple linear regression demonstrated that Co, I, and Li were directly related to circulating TSH levels, whereas V concentration was negatively interrelated. In turn, only serum Li levels were characterized by a significant direct relationship with free T3 values.

Conclusion: Generally, the obtained data demonstrate that altered serum trace elements are associated with thyroid dysfunction in acute ischemic stroke patients. However, the causal relationship should be estimated.