In many bacteria, separate genes encode a copper binding chaperone and a copper efflux pump, but in some the chaperone encoding gene has been elusive. In this issue of Molecular Cell, Meydan et al. (2017) report that ribosomes translating the ORF that encodes the copper pump frequently frameshift and terminate to produce the copper chaperone.
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http://dx.doi.org/10.1016/j.molcel.2017.01.002 | DOI Listing |
Redox Biochem Chem
December 2024
Food Chemistry with Focus on Toxicology, Faculty of Mathematics and Natural Sciences, University of Wuppertal, Germany.
While copper (Cu) is an essential trace element for biological systems due to its redox properties, excess levels may lead to adverse effects partly due to overproduction of reactive species. Thus, a tightly regulated Cu homeostasis is crucial for health. Cu dyshomeostasis and elevated labile Cu levels are associated with oxidative stress and neurodegenerative disorders, but the underlying mechanisms have yet to be fully characterized.
View Article and Find Full Text PDFInt J Biol Macromol
December 2024
Laboratory of Animal Developmental Biology, College of Life Science, Northeast Forestry University, Harbin 150040, China. Electronic address:
Hippo signaling plays a crucial role in the cellular response to various stressors, such as mechanical stress, metabolic stress, and hypoxic stress. However, its physiological significance in copper (Cu) stress remains poorly understood. Here, we demonstrated aberrant activation of Hippo-YAP signaling in sheep pancreas and pancreatic organoids exposed to excessive Cu, accompanied by significant pathological changes, elevated levels of oxidative stress, and impaired mitochondrial structure and function.
View Article and Find Full Text PDFFEBS J
December 2024
Instituto de Biología Molecular y Celular de Rosario (IBR), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)-Universidad Nacional de Rosario (UNR), Rosario, Argentina.
Physiol Plant
November 2024
Department of Botany, Panjab University, Chandigarh, India.
Int J Mol Sci
November 2024
Budker Institute of Nuclear Physics, Siberian Branch of Russian Academy of Sciences, 11 Akad. Lavrentiev Ave., 630090 Novosibirsk, Russia.
As areas of application of terahertz (THz) radiation expand in science and practice, evidence is accumulating that this type of radiation can affect not only biological molecules directly, but also cellular processes as a whole. In this study, the transcriptome in cells of the thermophilic bacterium was analyzed immediately after THz irradiation (0.23 W/cm, 130 μm, 15 min) and at 10 min after its completion.
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