Objective: Skin-sparing mastectomy (SSM) with immediate heterologous reconstruction is a safe oncological option in surgical therapy of early breast cancer. Permacol is an acellular dermal matrix (ADM) placed between the implant and the skin to improve lower pole projection and implant coverage. The aim of our study was to evaluate the outcome with a focus on patient satisfaction after 6 months and to analyze physical changes of ADM.

Methods: 10 patients who underwent SSM with Permacol were analyzed retrospectively. All patients were followed using a satisfaction questionnaire and an ultrasound evaluation of the tissue thickness of the pectoralis muscle and the Permacol.

Results: No intraoperative complications were observed. One patient required removal of the implant for necrosis after 3 months. Half of the patients underwent secondary corrective surgery. A statistically significant thinning of the pectoralis muscle was observed, compared to the thickening of the Permacol. A majority of the patients were satisfied with the operation, and we found a correlation between lower body mass index and patient satisfaction.

Conclusion: In our small case series Permacol-assisted immediate reconstruction is shown to be an option for selected cases. Physical changes of Permacol result in a symmetrical coverage of the implant, which may improve cosmetic outcome.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5213735PMC
http://dx.doi.org/10.3389/fmed.2016.00072DOI Listing

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