AI Article Synopsis
- Researchers discovered and optimized a series of spirocyclic piperidine compounds that inhibit aldosterone synthase (CYP11B2).
- These inhibitors demonstrate strong potency in blocking CYP11B2 with good selectivity against similar enzymes.
- The compounds also exhibit favorable physical and pharmacokinetic properties, making them promising candidates for further development.
Article Abstract
Herein we report the discovery and hit-to-lead optimization of a series of spirocyclic piperidine aldosterone synthase (CYP11B2) inhibitors. Compounds from this series display potent CYP11B2 inhibition, good selectivity versus related CYP enzymes, and lead-like physical and pharmacokinetic properties.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5238464 | PMC |
| http://dx.doi.org/10.1021/acsmedchemlett.6b00455 | DOI Listing |
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