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Discovery of Novel Seven-Membered Prostacyclin Analogues as Potent and Selective Prostaglandin FP and EP3 Dual Agonists. | LitMetric
A novel series of prostaglandin analogues with a seven-membered ring scaffold was designed, synthesized, and evaluated for the functional activation of prostaglandin receptors to identify potent and subtype-selective FP and EP3 dual agonists. Starting from the prostacyclin derivative , a nonselective agonist for prostaglandin receptors, replacement of the core structure with an octahydro-2-cyclopenta[]oxepine scaffold led to the discovery of the potent and selective FP and EP3 dual agonist as a lead compound for the development of an antiglaucoma agent.
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