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Pancreatic Eosinophilic Infiltrates of Infants of Diabetic Mothers Revisited.
Fetal Pediatr Pathol
December 2024
Laboratory, Children's Hospital of New Orleans, Department of Pathology, Louisiana State University Health Sciences Center, New Orleans, LA, USA.
Infants of diabetic mothers (IDM) frequently show eosinophilic infiltrates around the pancreatic islets. We review 2 IDM, describe the pancreatic histology and review the literature. Two term IDM died at 1 h and 43 days respectively.
View Article and Find Full Text PDFThe impact of Charcot-Leyden Crystal protein on mesothelioma chemotherapy: targeting eosinophils for enhanced chemosensitivity.
EBioMedicine
November 2024
Molecular and Cellular Epigenetics (GIGA) and Molecular Biology (TERRA), University of Liege, Liege & Gembloux, Belgium. Electronic address:
Background: In mesothelioma (MPM), clinical evidence indicates that the absolute eosinophil count negatively correlates with overall survival and response to standard chemotherapy. Since eosinophils poorly infiltrate MPM tumours, we hypothesised that endocrine rather than paracrine pathways mediate the therapeutic response. We thus studied the effect of eosinophil-associated factors on response to chemotherapy in mesothelioma.
View Article and Find Full Text PDFWhen the Nose Meets the Lab: Histopathological Analysis in Chronic Rhinosinusitis with Nasal Polyps for Routine Clinical Practice.
Curr Allergy Asthma Rep
December 2024
Rhinology Unit & Smell Clinic, ENT Department, Hospital Clinic Barcelona, FRCB-IDIBAPS, CIBERES, Barcelona, Spain.
Article Synopsis
- The review focuses on the importance of histopathological analysis of tissue samples in chronic rhinosinusitis with nasal polyps (CRSwNP) to enhance understanding and treatment options.
- It highlights that the severity of CRSwNP correlates with factors like eosinophil levels in nasal polyps, and discusses ongoing debates over biopsy methods and sample locations.
- A pragmatic checklist has been proposed by a panel of experts to standardize tissue analysis, improve communication among healthcare providers, and help identify CRSwNP subtypes for better-targeted therapies.
Presence of sputum IgG against eosinophilic inflammatory proteins in asthma.
Front Immunol
August 2024
State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health; Department of Allergy and Clinical Immunology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Background: Sputum immunoglobulin G (Sp-IgG) has been discovered to induce cytolytic extracellular trap cell death in eosinophils, suggesting a potential autoimmune mechanism contributing to asthma. This study aimed to explore the potential origin of Sp-IgG and identify clinically relevant subtypes of Sp-IgG that may indicate autoimmune events in asthma.
Methods: This study included 165 asthmatic patients and 38 healthy volunteers.
Atypical -Induced Hepatic Visceral Larva Migrans: Diagnostic Challenges and Literature Review.
Korean J Gastroenterol
June 2024
Department of Internal Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Vietnam.
Article Synopsis
- Toxocariasis is a zoonotic infection from dog and cat larvae that can pose serious health risks to humans, with a case described involving a 21-year-old male who had close contact with a pet dog.
- The patient's symptoms initially resembled a common liver abscess, with lab results showing elevated white blood cells and IgE levels, but persistent fever led to more testing revealing a Toxocara-induced liver abscess.
- Successful treatment with albendazole demonstrated significant improvement, highlighting the importance of considering toxocariasis in liver abscess cases, especially in regions with high rates of infection, and the need for thorough diagnostic methods beyond serological tests.
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