AI Article Synopsis
- Cytomegalovirus (CMV) shows genetic variation, affecting how antivirals and vaccines are developed.
- Most research has concentrated on lab-adapted strains that grow on fibroblast cells.
- This study provides whole-genome sequences for 10 strains of human cytomegalovirus that can grow on ARPE-19 cells, which are human retinal pigment epithelial cells.
Article Abstract
Cytomegalovirus displays genetic heterogeneity, which has implications for antiviral and vaccine development. Many studies have focused on laboratory isolates that have been extensively adapted for growth on fibroblasts. Here, we report whole-genome sequences for 10 human cytomegalovirus (HCMV) strains that readily grow on ARPE-19 human retinal pigment epithelial cells.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5255926 | PMC |
| http://dx.doi.org/10.1128/genomeA.01433-16 | DOI Listing |
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