We recently identified PHF13 as an H3K4me2/3 chromatin reader and transcriptional co-regulator. We found that PHF13 interacts with RNAPIIS5P and PRC2 stabilizing their association with active and bivalent promoters. Furthermore, mass spectrometry analysis identified ∼50 spliceosomal proteins in PHF13s interactome. Here, we will discuss the potential role of PHF13 in RNAPII pausing and co-transcriptional splicing.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423499 | PMC |
| http://dx.doi.org/10.1080/21541264.2016.1274813 | DOI Listing |
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