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HIV-1 Antiretroviral Drug Resistance in Mozambique: A Systematic Review and Meta-Analysis.
Viruses
November 2024
Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa, Avenida Professor Gama Pinto, 1649-003 Lisbon, Portugal.
Article Synopsis
- The systematic review analyzed HIV drug resistance in Mozambique, finding significant levels of resistance mutations in drug-naive and ART-experienced individuals, particularly to NNRTIs and NRTIs.
- Drug resistance mutations were more prevalent in the region of Beira and among pediatric patients compared to adults and pregnant women.
- The study emphasizes the need for ongoing surveillance and targeted interventions to improve ART regimens and public health strategies, particularly for vulnerable populations.
Dendritic pathology and overexpression of MAP2 in Purkinje cells from mice inoculated with rabies virus.
J Mol Histol
December 2024
Grupo de Morfología Celular, Instituto Nacional de Salud (INS), Av. Calle 26 No. 51-20, Bogotá, DC, 111321, Colombia.
The effect of rabies virus infection on dendritic morphology and on the expression of the MAP2 protein in Purkinje cells in the cerebellum of mice was studied. ICR mice were inoculated with rabies virus, and six days later, the mice were sacrificed, the cerebellum was removed and processed for Golgi-Cox staining or MAP2 immunohistochemistry. Infection with rabies virus altered the dendritic pattern of Purkinje cells ranged from moderate changes to accentuated retraction in the dendritic tree of some Purkinje cells.
View Article and Find Full Text PDFGenomic analysis of DS-1-like human rotavirus A strains uncovers genetic relatedness of NSP4 gene with animal strains in Manhiça District, Southern Mozambique.
Sci Rep
December 2024
Centro de Investigação em Saúde de Manhiça (CISM), Maputo, Mozambique.
Post rotavirus vaccine introduction in Mozambique (September 2015), we documented a decline in rotavirus-associated diarrhoea and genotypes changes in our diarrhoeal surveillance spanning 2008-2021. This study aimed to perform whole-genome sequencing of rotavirus strains from 2009 to 2012 (pre-vaccine) and 2017-2018 (post-vaccine). Rotavirus strains previously detected by conventional PCR as G2P[4], G2P[6], G3P[4], G8P[4], G8P[6], and G9P[6] from children with moderate-to-severe and less-severe diarrhoea and without diarrhoea (healthy community controls) were sequenced using Illumina MiSeq platform and analysed using bioinformatics tools.
View Article and Find Full Text PDFNeutralizing antibody correlate of protection against severe-critical COVID-19 in the ENSEMBLE single-dose Ad26.COV2.S vaccine efficacy trial.
Nat Commun
November 2024
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Assessment of immune correlates of severe COVID-19 has been hampered by the low numbers of severe cases in COVID-19 vaccine efficacy (VE) trials. We assess neutralizing and binding antibody levels at 4 weeks post-Ad26.COV2.
View Article and Find Full Text PDFSewer transport conditions and their role in the decay of endogenous SARS-CoV-2 and pepper mild mottle virus from source to collection.
Int J Hyg Environ Health
January 2025
Department of Civil Engineering, University of Ottawa, Ottawa, K1N 6N5, Canada. Electronic address:
Article Synopsis
- The study investigates the decay patterns of SARS-CoV-2 and Pepper mild mottle virus (PMMoV) in wastewater contaminated with stool samples from COVID-19 patients, aiming to reflect real-world conditions better than traditional laboratory methods.
- It examines how these viruses decay under two specific sewer transport conditions—dynamic suspended transport and bed/near-bed transport—across varying temperatures (4°C, 12°C, and 20°C).
- Results show no significant decay of SARS-CoV-2 or PMMoV in dynamic suspended transport over 35 hours, while significant decay occurs in bed/near-bed conditions, especially for PMMoV, which shows higher decay rates at elevated temperatures.
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