Systemic inflammation is a recognized feature in chronic kidney disease (CKD). The role of systemic inflammation in the pathogenesis of vascular calcification was recently settled. FGF23 was recently accused as a direct stimulus of systemic inflammation. This finding explains the strong association of FGF23 to vascular calcification and increased mortality among CKD.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215210 | PMC |
| http://dx.doi.org/10.5527/wjn.v6.i1.57 | DOI Listing |
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