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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5218941PMC
http://dx.doi.org/10.1007/s12262-016-1527-5DOI Listing

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Invasive mucormycosis is an aggressive fungal infection characterized by rapid progression, primarily impacting immunocompromised individuals. Herein, we report a case of splenic infarction in association with gastrointestinal fistula and brain abscess as a rare presentation of mucormycosis biopsy, proven in a 56-year-old patient diagnosed with acute myeloid leukemia. The patient initially sought medical attention with a 3-week history of fever, night sweats, and malaise.

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Mucormycosis is a rare deep fungal infection that develops mainly in immunosuppressed patients, being unusual the gastrointestinal presentation. The adequate treatment consists in rapid and aggressive surgical debridement, along with initial adjuvant treatment with liposomal amphotericin B. Despite recent advances in the management of this disease, the prognosis is poor, with a high mortality rate.

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Background: Mucormycosis is a highly lethal opportunistic fungal disease caused by ubiquitous molds of the order Mucorales, with Rhizopus, Lichtheimia and Mucor being the most common genera. This rare disease primarily affects immunocompromised patients, with presentations ranging from rhino-orbito-cerebral infections to disseminated mucormycosis with angioinvasion, leading to thrombosis and tissue infarction. Gastrointestinal mucormycosis is the least common clinical presentation and is believed to be secondary to spore ingestion.

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Article Synopsis
  • - Gastrointestinal mucormycosis is a rare but severe fungal infection that primarily affects the stomach and can be particularly deadly in individuals with weakened immune systems, like those with Crohn's disease.
  • - Patients with Crohn's disease often face complications like perianal involvement, which can be debilitating and may necessitate aggressive treatment, including immunosuppressive therapies.
  • - The case of a middle-aged woman with perianal Crohn's disease on adalimumab who developed colonic mucormycosis illustrates the importance of recognizing fungal infections as potential triggers for flare-ups in inflammatory bowel disease.
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