AI Article Synopsis
- Researchers analyzed bovine serum from 715 calves in the U.S. using viral metagenomics, leading to the discovery of two parvoviruses: bovine parvovirus 2 (BPV2) and a new one named bosavirus (BosaV).
- The study revealed that bosavirus fits into a new species within the copiparvovirus genus based on its NS1 protein identity.
- Additionally, low levels of other viruses like ungulate tetraparvovirus 2 and bovine hepacivirus were detected, highlighting the diversity of viruses present in calf serum that could affect fetuses and contaminate cell cultures through fetal bovine serum.
Article Abstract
Using viral metagenomics we analyzed four bovine serum pools assembled from 715 calves in the United States. Two parvoviruses, bovine parvovirus 2 (BPV2) and a previously uncharacterized parvovirus designated as bosavirus (BosaV), were detected in 3 and 4 pools respectively and their complete coding sequences generated. Based on NS1 protein identity, bosavirus qualifies as a member of a new species in the copiparvovirus genus. Also detected were low number of reads matching ungulate tetraparvovirus 2, bovine hepacivirus, and several papillomaviruses. This study further characterizes the diversity of viruses in calf serum with the potential to infect fetuses and through fetal bovine serum contaminate cell cultures.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654489 | PMC |
| http://dx.doi.org/10.1016/j.biologicals.2016.12.009 | DOI Listing |
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