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Dissociable roles of central striatum and anterior lateral motor area in initiating and sustaining naturalistic behavior.
Cell Rep
January 2025
Center for the Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA, USA; Center for Neuroscience, University of Pittsburgh, Pittsburgh, PA, USA; Translational Neuroscience Program, Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:
Understanding how corticostriatal circuits mediate behavioral selection and initiation in a naturalistic setting is critical to understanding behavior choice and execution in unconstrained situations. The central striatum (CS) is well poised to play an important role in these spontaneous processes. Using fiber photometry and optogenetics, we identify a role for CS in grooming initiation.
View Article and Find Full Text PDFImpaired macroscopic CSF flow by sevoflurane in humans - both during and after anesthesia.
Anesthesiology
January 2025
Department of Neuroradiology, School of Medicine and Health, Technical University of Munich, Germany.
Background: According to the model of the glymphatic system, the directed flow of cerebrospinal fluid (CSF) is a driver of waste clearance from the brain. In sleep, glymphatic transport is enhanced, but it is unclear how it is affected by anesthesia. Animal research indicates partially opposing effects of distinct anesthetics but corresponding results in humans are lacking.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
New York State Psychiatric Institute, New York, NY, USA.
Background: While the association between sleep quality and brain health is well established, the role of aging in this relationship is largely unknown. This study aimed to examine the interaction between sleep and age on cortical thickness using samples from large-scale cohort studies. Age was examined in both linear and non-linear (quadratic) terms, in order to determine the presence of critical age ranges that may exhibit more significant sleep-related brain structural changes.
View Article and Find Full Text PDFTranstracheal Ultrasound as a Preventive Tool for ETT Related Adverse Events and Malpositioning in the ICU.
J Intensive Care Med
January 2025
The George Washington University School of Medicine and Health Sciences, Washington, DC, USA.
Introduction: Endotracheal tube (ETT) malpositioning can result in a myriad of complications. Daily chest radiographs (CXR) is the gold standard in monitoring these complications. Point-of-care transtracheal ultrasound (TTUS) is an emerging imaging modality for ETT positioning.
View Article and Find Full Text PDFCerebral white matter damage in patients with end-stage kidney disease associates with cognitive impairment.
Clin Kidney J
January 2025
Healthy Aging Research Center, Chang Gung University, Taoyuan City, Taiwan.
Background: Damage to brain white matter often occurs in individuals with chronic kidney disease, which might be related to their cognitive decline. This study aims to investigate tract-specific white matter damage in patients with end-stage kidney disease by using fixel-based analysis.
Methods: Images of 31 end-stage kidney disease patients and 16 normal controls (aged: 61.
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