In this work, we evaluate the interaction of the peripheral Pt(bpy)Cl substituted porphyrins, H2PtPor and ZnPtPor with DNA using UV-vis, emission fluorescence, CD spectroscopy, and DNA melting properties altered by the Pt(ii)-porphyrinoid compounds. Additionally, we observe the ability of these porphyrin derivatives to generate O and to efficiently photocleave plasmid DNA upon visible light irradiation based on a mixed (oxidative/hydrolytic) mechanism.
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