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Copper(i)/TF-BiphamPhos catalyzed asymmetric nitroso Diels-Alder reaction. | LitMetric

Copper(i)/TF-BiphamPhos catalyzed asymmetric nitroso Diels-Alder reaction.

Chem Commun (Camb)

College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China.

Published: February 2017

AI Article Synopsis

Article Abstract

A highly efficient enantioselective nitroso Diels-Alder reaction of 6-methyl-2-nitroso pyridine with various 1,3-dienes was successfully developed using a Cu(i)/(S)-TF-BiphamPhos complex as the catalyst. For most of the cyclic dienes, synthetically important heterocyclic 3,6-dihydro-1,2-oxazines were obtained in high yields with excellent regio-, diastereo- and enantioselectivities. Acyclic 2-silyloxy-1,3-diene also worked well in the reaction.

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Source
http://dx.doi.org/10.1039/c6cc09587aDOI Listing

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