AI Article Synopsis
- - An efficient and quick method for complexing scandium (Sc) with the chelating agent AAZTA was achieved under mild conditions.
- - The stability of the Sc(AAZTA) chelate and its attached biomolecules was demonstrated through PET imaging tests in both healthy and tumor-bearing mice.
- - These findings open up new possibilities for creating effective Sc-based radiopharmaceuticals using AAZTA as a chelator.
Article Abstract
Unprecedented fast and efficient complexation of Sc was demonstrated with the chelating agent AAZTA (AAZTA=1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-6-methylperhydro-1,4-diazepine) under mild experimental conditions. The robustness of the Sc(AAZTA) chelate and conjugated biomolecules thereof is further shown by in vivo PET imaging in healthy and tumor mice models. The new results pave the way towards development of efficient Sc-based radiopharmaceuticals using the AAZTA chelator.
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| http://dx.doi.org/10.1002/anie.201611207 | DOI Listing |
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