AI Article Synopsis
- The main cytotoxic compounds from the marine organism Lissoclinum patella have been extracted and analyzed, with a focus on ulithiacyclamide B, a novel cyclic peptide.
- The structure of ulithiacyclamide B has been proposed based on various spectroscopic techniques and tests confirming its chemical stability.
- While ulithiacyclamide B shows significant cytotoxic effects against the KB cancer cell line, it does not selectively target solid tumor cells according to the Corbett assay results.
Article Abstract
The major cytotoxic metabolites of Lissoclinum patella from Pohnpei have been isolated and identified. Most of the cytotoxicity is attributed to a new cyclic peptide, ulithiacyclamide B [4], which is closely related to ulithiacyclamide [1]. The proposed structure of 4 is based on spectroscopic analysis and chemical degradation. Compound 4 exhibits an IC50 of 17 ng/ml against the KB cell line but does not show selective cytotoxicity against solid tumor cells in the Corbett assay.
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| http://dx.doi.org/10.1021/np50064a011 | DOI Listing |
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