AI Article Synopsis
- Chlamydiae are harmful pathogens that can cause significant reproductive and health issues in humans.
- In a study searching for new antimicrobial substances, researchers isolated one new and two known dimeric indole derivatives from a sponge-derived microorganism.
- The most effective compound showed strong antichlamydial activity by inhibiting the growth of Chlamydia during a specific phase of its life cycle, without directly inactivating its infectious form.
Article Abstract
Chlamydiae are widely distributed pathogens of human populations, which can lead to serious reproductive and other health problems. In our search for novel antichlamydial metabolites from marine derived-microorganisms, one new () and two known () dimeric indole derivatives were isolated from the sponge-derived actinomycete . The chemical structures of these metabolites were elucidated by NMR spectroscopic data as well as CD calculations. All three metabolites suppressed chlamydial growth in a concentration-dependent manner. Among them, compound exhibited the most effective antichlamydial activity with IC values of 46.6 ~ 96.4 µM in the production of infectious progeny. Compounds appeared to target the mid-stage of the chlamydial developmental cycle by interfering with reticular body replication, but not directly inactivating the infectious elementary body.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660345 | PMC |
| http://dx.doi.org/10.1055/s-0043-100382 | DOI Listing |
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