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Seizures and premature death in mice with targeted Kv1.1 deficiency in corticolimbic circuits.
Brain Commun
January 2025
Department of Biological Sciences, Southern Methodist University, Dallas, TX 75275, USA.
Sudden unexpected death in epilepsy (SUDEP) is the leading cause of epilepsy-related death, likely stemming from seizure activity disrupting vital brain centres controlling heart and breathing function. However, understanding of SUDEP's anatomical basis and mechanisms remains limited, hampering risk evaluation and prevention strategies. Prior studies using a neuron-specific conditional knockout mouse model of SUDEP identified the primary importance of brain-driven mechanisms contributing to sudden death and cardiorespiratory dysregulation; yet, the underlying neurocircuits have not been identified.
View Article and Find Full Text PDFHippocampal area CA2 activity supports social investigation following an acute social stress.
Mol Psychiatry
November 2024
Neurobiology Laboratory, National Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, NC, 27713, USA.
Neuronal activity in the hippocampus is critical for many types of memory acquisition and retrieval and influences an animal's response to stress. Moreover, the molecularly distinct principal neurons of hippocampal area CA2 are required for social recognition memory and aggression in mice. To interrogate the effects of stress on CA2-dependent behaviors, we chemogenetically manipulated neuronal activity in vivo during an acute, socially derived stressor and tested whether memory for the defeat was influenced.
View Article and Find Full Text PDFArticle Synopsis
- The study focuses on how Alzheimer's disease (AD) affects decision-making by analyzing neural activity in 5XFAD mice, which have severe amyloid pathology.
- Using food approach and predator avoidance tasks, the research found that these mice exhibit poor decision-making strategies, with specific neural issues like rigid hippocampal place fields and reduced sharp-wave ripple frequencies.
- The findings suggest that disruptions in neural connectivity and dynamics are linked to decision-making problems in AD, highlighting opportunities for developing targeted therapies to improve cognitive function.
Resting-state functional magnetic resonance imaging alterations in first-degree relatives of individuals with bipolar disorder: A systematic review.
J Affect Disord
November 2024
Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Background: Relatives of individuals with bipolar disorder (BD) are at higher risk of developing the disorder. Identifying brain alterations associated with familial vulnerability in BD can help discover endophenotypes, which are quantifiable biological traits more prevalent in unaffected relatives of BD (BD-RELs) than the general population. This review aimed at expanding our knowledge on endophenotypes of BD by providing an overview of resting-state functional magnetic resonance imaging (rs-fMRI) alterations in BD-RELs.
View Article and Find Full Text PDFThe Pathobiology of Behavioral Changes in Multiple System Atrophy: An Update.
Int J Mol Sci
July 2024
Institute of Clinical Neurobiology, Alberichgasse 5/13, 1150 Vienna, Austria.
While cognitive impairment, which was previously considered a red flag against the clinical diagnosis of multiple system atrophy (MSA), is a common symptom of this rare neurodegenerative disorder, behavioral disorders are reported in 30 to 70% of MSA patients. They include anxiety, apathy, impaired attention, compulsive and REM sleep behavior disorders (RBD), and these conditions, like depression, are early and pervasive features in MSA, which may contribute to disease progression. Despite changing concepts of behavioral changes in this synucleinopathy, the underlying pathophysiological and biochemical mechanisms are poorly understood.
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