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Dietary Fat Consumption and Non-Hodgkin's Lymphoma Risk: A Meta-analysis. | LitMetric

Dietary Fat Consumption and Non-Hodgkin's Lymphoma Risk: A Meta-analysis.

Nutr Cancer

a Department of Hematology , Shandong Provincial Hospital, Shandong University, Tai'an , China.

Published: January 2018

AI Article Synopsis

Article Abstract

Objective: Many studies suggest that high-fat diets are linked to the etiology of non-Hodgkin's lymphoma (NHL). However, the findings are inconsistent and therefore the association between fat and non-Hodgkin's lymphoma remains unclear. In this study, we aim to quantitatively assess the association between fat consumption and the risk for NHL.

Methods: We reviewed 221 published cohort and case-control studies that reported relative risk (RRs) and corresponding 95% confidence intervals (CIs) of NHL and fat intake using PubMed, Cochrane, EMBASE, and Google Scholar databases. A random-effects model computed summary risk estimates.

Results: Based on our literature search, 10 of 221 studies (two cohort and eight case-control studies) were relevant to this meta-analysis. There was a significant association between total fat consumption and increased risk of NHL (RR = 1.26; 95% CI: 1.12-1.42); in addition, subgroup analysis showed a significant correlation with diffuse large B-cell lymphoma (RR = 1.41; 95% CI: 1.08-1.84) but not with follicular lymphoma (RR = 1.21; 95% CI: 0.97-1.52), small lymphocytic lymphoma/chronic lymphocytic leukemia (RR = 0.91; 95% CI: 0.68-1.23), nor with T cell lymphoma (RR = 1.12; 95% CI: 0.60-2.09). The funnel plot revealed no evidence for publication bias.

Conclusion: Total fat consumption, particularly animal fat, increases the risk for NHL.

Download full-text PDF

Source
http://dx.doi.org/10.1080/01635581.2017.1263753DOI Listing

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