AI Article Synopsis
- Silver-based devices activated by low intensity direct current (LIDC) show promise for localized antimicrobial treatment due to their ability to generate silver ions at the implantation site.
- In vitro tests indicated that these devices effectively killed methicillin-resistant Staphylococcus aureus (MRSA) over 48 hours at specified current levels, demonstrating strong antibacterial activity.
- However, while the system was effective against bacteria, it also exhibited cytotoxic effects on nearby human cells, indicating a trade-off between antimicrobial efficacy and potential harm to tissues.
Article Abstract
Silver-based devices activated by electric current are of interest in biomedicine because of their broad-spectrum antimicrobial activity. This study investigates the in vitro antibacterial efficacy and cytotoxicity of a low intensity direct current (LIDC)-activated silver-titanium implant system prototype designed for localized generation and delivery of silver ions at the implantation site. First, the antibacterial efficacy of the system was assessed against methicillin-resistant Staphylococcus aureus (MRSA) over 48 h at current levels of 3 and 6 µA in Mueller-Hinton broth. The cytotoxicity of the system was then evaluated over 48 h in two phases using an in vitro model with in which the activated electrodes were suspended in growth medium in a cell-seeded tissue culture plate. In phase-1, the system was tested on human osteosarcoma (MG-63) cell line and compared to titanium controls. In phase-2, the cytotoxicity characteristics were validated with normal human diploid osteoblast cells. The LIDC-activated system demonstrated high antimicrobial efficacy against MRSA, but was also toxic to human cells immediately surrounding the electrodes. The statistical analysis showed that the cytotoxicity was a result of the presence of silver, and the electric activation did not make it worse.
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| http://dx.doi.org/10.1007/s10534-017-9993-1 | DOI Listing |
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