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A Tale of Two Medicines: The Need for Ownership, End-to-End Planning and Execution for Development and Introduction of Maternal Health Medicines.
Int J MCH AIDS
September 2024
Concept Foundation, Avenue de Sécheron, Geneva, Switzerland.
Article Synopsis
- - Postpartum hemorrhage (PPH) is a leading cause of maternal death in low- and middle-income countries (LMICs), and the WHO recommends heat-stable carbetocin and tranexamic acid to prevent and treat it.
- - Implementation of these recommended drugs is hindered by issues like disorganized procurement, poor quality control, and limited access in many LMICs.
- - Despite having safety and efficacy data, access challenges differ between the two drugs, necessitating coordinated actions for better availability of essential maternal health commodities.
Seasonal variation in thermal tolerance and hypoxia tolerance of a threatened minnow and a non-imperilled congener: a cautionary tale for surrogate species in conservation.
Conserv Physiol
October 2024
Department of Biology, McGill University, 1205 Dr Penfield Avenue, Montreal, Quebec, Canada.
Article Synopsis
- Freshwater organisms are facing increasing threats from climate change and low oxygen levels, impacting their ecosystems.
- This study compares the physiological performance of the Threatened Pugnose Shiner and the non-imperilled Blackchin Shiner to understand their tolerance to environmental stressors like hypoxia and temperature.
- Results indicate that Pugnose Shiner is more sensitive to climate-related stressors and suggests that using surrogate species may not always provide accurate data for imperilled species' conservation.
Catchers of folding gone awry: a tale of small heat shock proteins.
Trends Biochem Sci
December 2024
School of Natural Sciences, and Department Bioscience, Center for Functional Protein Assemblies, Technical University Munich, Ernst-Otto-Fischer Str. 8, 85748 Garching, Germany. Electronic address:
Article Synopsis
- - Small heat shock proteins (sHsps) help maintain protein balance in cells during normal and stressful situations by acting as molecular chaperones that form complexes with misfolded proteins without using ATP.
- - sHsps exist in various sizes and shapes, and their efficiency as chaperones is regulated by the balance between these different forms, allowing them to effectively trap and manage damaged proteins.
- - The review highlights recent findings on the structure and function of sHsp oligomers, exploring their significance in aging processes and in maintaining transparency in eye lenses.
A tale of two blooms: do ecological paradigms for algal bloom success and succession require revisiting?
J Great Lakes Res
June 2024
Department of Microbiology, The University of Tennessee, Knoxville, TN, USA.
Lake Erie algal bloom discussions have historically focused on cyanobacteria, with foundational "blooms like it hot" and "high nutrient" paradigms considered as primary drivers behind cyanobacterial bloom success. Yet, recent surveys have rediscovered winter-spring diatom blooms, introducing another key player in the Lake Erie eutrophication and algal bloom story which has been historically overlooked. These blooms (summer winter) have been treated as solitary events separated by spatial and temporal gradients.
View Article and Find Full Text PDFThe clade III subfamily of OsSWEETs directly suppresses rice immunity by interacting with OsHMGB1 and OsHsp20L.
Plant Biotechnol J
August 2024
State Key Laboratory of Hybrid Rice, Hubei Hongshan Laboratory, College of Life Sciences, Wuhan University, Wuhan, China.
The clade III subfamily of OsSWEETs includes transmembrane proteins necessary for susceptibility to bacterial blight (BB). These genes are targeted by the specific transcription activator-like effector (TALE) of Xanthomonas oryzae pv. oryzae and mediate sucrose efflux for bacterial proliferation.
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