AI Article Synopsis
- A case involving a 16-year-old girl revealed an incidental finding of renal cell carcinoma (RCC) during staging for Hodgkin lymphoma, which is uncommon in children.
- Despite genetic tests showing no common mutations for RCC, the tumor displayed a rare chromosomal translocation.
- Following surgery and chemotherapy, the girl is now cancer-free, emphasizing the need for careful evaluation of kidney masses in patients with other cancers.
Article Abstract
Background: Coincidence of renal cell carcinoma (RCC) and hematologic malignancies has been reported in adults but not in children.
Observation: We report a case of a 16-year-old girl in whom RCC was incidentally discovered on the computed tomography scan that was performed to stage her underlying Hodgkin lymphoma. Analysis of constitutional cytogenetics for common genetic aberrations that predispose to RCC did not reveal any mutations or genetic variations. However, cytogenetics on the RCC tumor demonstrated a rare reciprocal translocation between chromosomes 6 and 11, t(6;11)(p21;q12). After undergoing partial nephrectomy with regional lymphadenectomy and treatment with multiagent chemotherapy, patient is cancer-free, now 33 months from end of therapy.
Conclusions: This case highlights the importance for histologic confirmation of a renal mass when concurrently discovered during the diagnostic evaluation of other malignancies.
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| http://dx.doi.org/10.1097/MPH.0000000000000769 | DOI Listing |
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