AI Article Synopsis
- - Long non-coding RNAs (lncRNAs) play crucial roles in various biological processes, and a new lncRNA called Linc-RAM is identified as a key activator of muscle development, particularly under the regulation of MyoD.
- - Linc-RAM is expressed specifically in skeletal muscle cells and increases during muscle development, with experiments showing that mice lacking Linc-RAM have difficulty regenerating muscle due to problems with satellite cell differentiation.
- - The mechanism of Linc-RAM involves its direct interaction with MyoD, facilitating the formation of a complex that helps activate myogenic genes and promote chromatin changes needed for muscle-specific gene expression.
Article Abstract
Long non-coding RNAs (lncRNAs) are important regulators of diverse biological processes. Here we report on functional identification and characterization of a novel long intergenic non-coding RNA with MyoD-regulated and skeletal muscle-restricted expression that promotes the activation of the myogenic program, and is therefore termed Linc-RAM (Linc-RNA Activator of Myogenesis). Linc-RAM is transcribed from an intergenic region of myogenic cells and its expression is upregulated during myogenesis. Notably, in vivo functional studies show that Linc-RAM knockout mice display impaired muscle regeneration due to the differentiation defect of satellite cells. Mechanistically, Linc-RAM regulates expression of myogenic genes by directly binding MyoD, which in turn promotes the assembly of the MyoD-Baf60c-Brg1 complex on the regulatory elements of target genes. Collectively, our findings reveal the functional role and molecular mechanism of a lineage-specific Linc-RAM as a regulatory lncRNA required for tissues-specific chromatin remodelling and gene expression.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241866 | PMC |
| http://dx.doi.org/10.1038/ncomms14016 | DOI Listing |
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