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A Rare Pediatric Giant Cell Tumor of the Clivus Bone, H3.3 p.Gly35Trp-mutated: Case Report and Mini-review of the Literature.
Turk Arch Pediatr
January 2025
Pathology Unit, IRCCS Istituto Giannina Gaslini, Genova, Italy.
Introduction: Giant cell tumor of bone (GCTB) is a rare, typically benign neoplasm that primarily affects long bones in adults, with clival involvement being extremely rare, particularly in pediatric cases: a mini-review shows a total of 28 described cases, of which only 5 were truly pediatric (within 14 years of age). Surgery is the treatment of choice, and Denosumab is reported to be the most effective drug therapy. To date, the GCTB's molecular hallmark is the somatic mutation p.
View Article and Find Full Text PDFSignificance of Biogenetic Markers in Giant Cell Tumor Differentiation and Prognosis: A Narrative Review.
Diagnostics (Basel)
December 2024
Orthopedic Surgery, Macquarie University Hospital, Sydney, NSW 2113, Australia.
: Giant cell tumor of bone (GCTB) is a locally aggressive tumor. It accounts for only 5% of all bony tumors. Early diagnosis, and follow-up for recurrence is often difficult due to a lack of biogenetic markers.
View Article and Find Full Text PDFCoverage bias in small molecule machine learning.
Nat Commun
January 2025
Chair for Bioinformatics, Institute for Computer Science, Friedrich Schiller University Jena, Jena, Germany.
Small molecule machine learning aims to predict chemical, biochemical, or biological properties from molecular structures, with applications such as toxicity prediction, ligand binding, and pharmacokinetics. A recent trend is developing end-to-end models that avoid explicit domain knowledge. These models assume no coverage bias in training and evaluation data, meaning the data are representative of the true distribution.
View Article and Find Full Text PDF[Giant pericranial sinus with extensive occipital calvarium defect].
Zh Vopr Neirokhir Im N N Burdenko
December 2024
Irkutsk State Medical University, Irkutsk, Russia.
Background: Giant non-traumatic and non-iatrogenic cranial vault defects are poorly studied due to their rarity. Therefore, diagnosis and analysis of their causes are difficult. In available literature, we found only 4 cases of giant pericranial sinus accompanied by extensive cranial vault defects.
View Article and Find Full Text PDFExpression of β-catenin and MSX1 proteins during parrot pseudoteeth and goose denticulations and giant filiform papillae's early development.
Morphologie
December 2024
Laboratoire d'anatomie, biomécanique et organogenèse, faculté de médecine, université libre de Bruxelles, route de Lennik, 808, CP, 619, 1070 Bruxelles, Belgium.
Objective: To use immunohistochemistry to analyse the expression of MSX1 and β-catenin proteins during parrot pseudoteeth development and goose denticulations and giant filiform papillae ontogeny.
Material And Methods: Eggs were purchased from stockbreeders. Embryos from selected stages were removed and sliced.
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