Platforms trials are clinical trials that allow for concurrent evaluations of multiple treatments, thus allowing for more efficient and ethical studies compared to traditional two-arm trials. Conventional group-sequential multi-arm multi-stage (MAMS) designs use pre-specified stopping boundaries and treatment selection rules to determine if experimental treatments should be dropped. Flexible MAMS designs allow for interim modifications to the design plan without compromising error rates. Bayesian response adaptive randomization (BRAR) designs increase patient allocation to treatment arms that are performing well during the course of the trial. In this paper, we compare these two major methods and their extensions under several scenarios in the platform trials setting. Results show that BRAR and flexible MAMS designs have comparable power and type 1 error rate under varying simulated scenarios, allowing for addition of flexible treatment selection. BRAR outperforms flexible MAMS when there is a single effective treatment. Flexible MAMS designs are more efficient compared to BRAR when there are no effective treatments. BRAR performance increases as the probability of a treatment arm being dropped increases.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.cct.2017.01.003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Economic Considerations in Designs and Modifications of Multiarm, Multistage Adaptive and Adaptive Platform Randomized Controlled Trials: A Systematic Literature Review.
Value Health
November 2024
Health Economics Unit, Institute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, England, UK; Global Health and Global Surgery Unit, National Institute for Health and Care Research (NIHR), University of Birmingham, Birmingham, England, UK.
Objectives: There is uncertainty around whether, and under what circumstances, there is value in embedding economic considerations into multiarm, multistage (MAMS) adaptive, and adaptive platform trial designs. This systematic review was conducted to assess the analytical methods and factors that are considered when incorporating health economic analyses when designing and modifying MAMS adaptive and adaptive platform trials.
Methods: The review searched for health economic analyses, including planned analyses, of interventions assessed through MAMS adaptive, and adaptive platform trials.
Design considerations for Factorial Adaptive Multi-Arm Multi-Stage (FAST) clinical trials.
Trials
September 2024
Department of Neurosurgery, University of Louisville, Louisville, KY, USA.
Background: Multi-Arm, Multi-Stage (MAMS) clinical trial designs allow for multiple therapies to be compared across a spectrum of clinical trial phases. MAMS designs fall under several overarching design groups, including adaptive designs (AD) and multi-arm (MA) designs. Factorial clinical trials designs represent a combination of factorial and MAMS trial designs and can provide increased efficiency relative to fixed, traditional designs.
View Article and Find Full Text PDFConstructing MXene-based mixed-dimensional structure with multiple interfaces to optimize dielectric-magnetic synergistic effect for effective electromagnetic wave absorption.
J Colloid Interface Sci
January 2025
School of Materials Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing 210094, China. Electronic address:
Exploring efficient microwave absorbing materials (MAMs) which could convert electromagnetic (EM) energy into thermal energy represents an approbatory vision to reducing EM radiation and interference. Designing of mixed-dimensional structure with multiple interfaces represents the available target to investigate an ideal MAMs, which maximizes the superiority of mixed-dimensional structure in electromagnetic wave absorption (EMWA). Herein, we take full advantage of multiple interfaces engineering of MXene for optimizing the impedance matching to improve EMWA, MXene-based mixed-dimensional structure was designed by incorporating three-dimensional FeC@Carbon layers coated zero-dimensional FeO nanoparticles (NPs) supported two-dimensional MXene nanosheets (MXene/FeO@FeC@Carbon, MFC).
View Article and Find Full Text PDFEfficient Design of Broadband and Low-Profile Multilayer Absorbing Materials on Cobalt-Iron Magnetic Alloy Doped with Rare Earth Element.
Nanomaterials (Basel)
June 2024
School of Materials Science and Engineering, Nanjing University of Science and Technology, Nanjing 210094, China.
Magnetic metal absorbing materials have exhibited excellent absorptance performance. However, their applications are still limited in terms of light weight, low thickness and wide absorption bandwidth. To address this challenge, we design a broadband and low-profile multilayer absorber using cobalt-iron (CoFe) alloys doped with rare earth elements (REEs) lanthanum (La) and Neodymium (Nd).
View Article and Find Full Text PDFThe Use of Hexokinase 2-Displacing Peptides as an Anti-Neoplastic Approach for Malignant Peripheral Nerve Sheath Tumors.
Cells
July 2024
Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy.
Malignant Peripheral Nerve Sheath Tumors (MPNSTs) are aggressive sarcomas that can arise both sporadically and in patients with the genetic syndrome Neurofibromatosis type 1 (NF1). Prognosis is dismal, as large dimensions, risk of relapse, and anatomical localization make surgery poorly effective, and no therapy is known. Hence, the identification of MPNST molecular features that could be hit in an efficient and selective way is mandatory to envision treatment options.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!