Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351565 | PMC |
| http://dx.doi.org/10.18632/oncotarget.14000 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The brainstem reticular formation pivots abnormal neural transmission in the course of Anorexia Nervosa.
J Neural Transm (Vienna)
January 2025
Human Anatomy, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma 55, Pisa, 56100, PI, Italy.
Anorexia nervosa (AN) represents an eating disorder, which features the highest rate of mortality among all psychiatric disorders. The disease prevalence is increasing steadily, and an effective cure is missing. The neurobiology of the disease is largely unknown, and only a few studies were designed to disclose specific brain areas, where altered neural transmission may occur.
View Article and Find Full Text PDFDoes fragmented sleep mediate the relationship between deficits in sleep spindles and memory consolidation in schizophrenia?
Sleep Adv
December 2024
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Study Objectives: Sleep spindles, defining electroencephalographic oscillations of nonrapid eye movement (NREM) stage 2 sleep (N2), mediate sleep-dependent memory consolidation (SDMC). Spindles are also thought to protect sleep continuity by suppressing thalamocortical sensory relay. Schizophrenia is characterized by spindle deficits and a correlated reduction of SDMC.
View Article and Find Full Text PDFThe association among individual gray matter volume of frontal-limbic circuitry, fatigue susceptibility, and comorbid neuropsychiatric symptoms following COVID-19.
Neuroimage
February 2025
Department of Medical Imaging, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China. Electronic address:
Article Synopsis
- The study investigates the neurobiological factors that make individuals susceptible to fatigue after a mild COVID-19 infection, aiming to understand the link between brain structure and post-COVID neuropsychiatric symptoms.
- Researchers used neuropsychiatric assessments and MRI scans on individuals who had COVID-19 and a control group to analyze brain regions related to fatigue.
- Results indicate that specific brain areas, particularly the right dorsolateral prefrontal cortex, are linked to fatigue severity and can predict ongoing fatigue symptoms months after the infection, shedding light on the neural underpinnings of post-COVID conditions.
Light-exercise-induced dopaminergic and noradrenergic stimulation in the dorsal hippocampus: Using a rat physiological exercise model.
FASEB J
December 2024
Laboratory of Exercise Biochemistry and Neuroendocrinology, Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba, Japan.
Exercise activates the dorsal hippocampus that triggers synaptic and cellar plasticity and ultimately promotes memory formation. For decades, these benefits have been explored using demanding and stress-response-inducing exercise at moderate-to-vigorous intensities. In contrast, our translational research with animals and humans has focused on light-intensity exercise (light exercise) below the lactate threshold (LT), which almost anyone can safely perform with minimal stress.
View Article and Find Full Text PDFSpatial differences in gene expression across the dorsal raphe nucleus in a model of early Alzheimer's disease.
J Alzheimers Dis
January 2025
Department of Neuroscience and Pharmacology, University of Iowa, Iowa City, IA, USA.
Article Synopsis
- People with Alzheimer's disease experience early mood, sleep, and arousal changes due to brain changes, especially in the dorsal raphe nucleus (DRN), but it’s unclear why all serotonin-producing neurons are not equally affected.
- The study aimed to explore genetic factors that influence how susceptible or resistant these serotonin neurons are to Alzheimer's disease pathology using advanced spatial gene expression analysis in a mouse model.
- The results showed that specific genes related to AD are differently expressed in the DRN of these mice, and that the loss of serotonin neurons and tau pathology is particularly pronounced in a specific region of the DRN, highlighting the importance of studying genetic and regulatory factors in Alzheimer's.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!